Acute
myocardial infarction remains the leading cause of death in humans. Timely restoration of blood perfusion to ischemic myocardium remains the most effective strategy in the treatment of acute
myocardial infarction, which can significantly reduce morbidity and mortality. However, after restoration of blood flow and reperfusion, myocardial injury will aggravate and induce apoptosis of cardiomyocytes, a process called
myocardial ischemia-
reperfusion injury. Studies have shown that the loss and death of cardiomyocytes caused by oxidative stress,
iron load, increased lipid peroxidation,
inflammation and
mitochondrial dysfunction, etc., are involved in
myocardial ischemia-
reperfusion injury. In recent years, with the in-depth research on the pathology of
myocardial ischemia-
reperfusion injury, people have gradually realized that there is a new form of cell death in the pathological process of
myocardial ischemia-
reperfusion injury, namely ferroptosis. A number of studies have found that in the myocardial tissue of patients with acute
myocardial infarction, there are pathological changes closely related to ferroptosis, such as
iron metabolism disorder, lipid peroxidation, and increased
reactive oxygen species free radicals. Natural plant products such as
resveratrol,
baicalin, cyanidin-3-O-glucoside,
naringenin, and
astragaloside IV can also exert
therapeutic effects by correcting the imbalance of these ferroptosis-related factors and expression levels. Combining with our previous studies, this review summarizes the regulatory mechanism of natural plant products intervening ferroptosis in
myocardial ischemia-
reperfusion injury in recent years, in order to provide reference information for the development of targeted ferroptosis inhibitor drugs for the treatment of
cardiovascular diseases.