Construction of a prognostic signature of RFC5 immune-related genes in patients with cervical cancer.

Abstract

BACKGROUND:

Cervical cancer (CC) is a malignant tumor threatening women's health. Replication factor C (RFC) 5 is significantly highly expressed in CC tissues, and the immune microenvironment plays a crucial role in tumor initiation, progression, and metastasis.

OBJECTIVE:

To determine the prognostic role of RFC5 in CC, analyze the immune genes significantly associated with RFC5, and establish a nomogram to evaluate the prognosis of patients with CC.

METHODS:

High RFC5 expression in patients with CC was analyzed and verified through TCGA GEO, TIMER2.0, and HPA databases. A risk score model was constructed using RFC5-related immune genes identified using R packages. Combining the risk score model and clinical information of patients with CC, a nomogram was constructed to evaluate the prognosis of patients with CC.

RESULTS:

Comprehensive analysis showed that the risk score was a prognostic factor for CC. The nomogram could predict the 3-year overall survival of patients with CC.

CONCLUSIONS:

RFC5 was validated as a biomarker for CC. The RFC5 related immune genes were used to establish a new prognostic model of CC.

• Authors: Huaqiu Chen, Huanyu Xie, Yuanyuan Zhang, Guangming Wang
• Journal: Cancer biomarkers : section A of Disease markers (Cancer Biomark) Vol. 37 Issue 4 Pg. 261-277 ( 2023) ISSN: 1875-8592 [Electronic] Netherlands
• PMID: 37302025 (Publication Type: Journal Article)

Chemical References

• RFC5 protein, human
• Replication Protein C

Topics

• Humans
• Female
• Uterine Cervical Neoplasms (genetics)
• Prognosis
• Nomograms
• Cell Transformation, Neoplastic
• Databases, Factual
• Tumor Microenvironment (genetics)
• Replication Protein C