Abstract | Introduction:
Lung cancer is the leading cause of cancer death worldwide, and lung adenocarcinoma (LADC) is the most common lung cancer. Lung cancer has a distinct microbiome composition correlated with patients' smoking status. However, the causal evidence of microbial impacts on LADC is largely unknown. Methods: Results and Discussion: We found a significant increase of genus Stenotrophomonas in LADC tissues of patients with primary tumor size greater than 3 cm and never-smoker patients. We further found that intratracheal infection with S. maltophilia promoted tumor progression in the NNK-induced lung cancer mouse model. We performed RNA-seq analysis on lung tissues and found that S. maltophilia treatment drove inflammation and upregulated tumor associated cell signaling, including Apelin signaling pathway. Mechanistically, histone deacetylase 5 (HDAC5) gene expression was significantly upregulated in S. maltophilia treated groups, and was required for S. maltophilia induced cell proliferation and migration in LADC cell line A549. Therefore, we provide in vivo and in vitro evidence to demonstrate that S. maltophilia promotes LADC progression, in part, through HDAC5.
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Authors | Jiyu Shen, Yalan Ni, Qijie Guan, Rui Li, Hong Cao, Yan Geng, Qingjun You |
Journal | Frontiers in microbiology
(Front Microbiol)
Vol. 14
Pg. 1121863
( 2023)
ISSN: 1664-302X [Print] Switzerland |
PMID | 36819033
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Shen, Ni, Guan, Li, Cao, Geng and You. |