Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model.

Abstract

Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure, particularly spleen dysfunction. In 2017, the worldwide incidence was 48.9 million sepsis cases and 11 million sepsis-related deaths were reported (Rudd et al., 2020). Inflammation, oxidative stress, and apoptosis are the most common pathologies seen in sepsis. Liensinine (LIE) is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera. Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects. It can exert anti-carcinogenic activity by regulating cell, inflammation, and apoptosis signaling pathways (Manogaran et al., 2019). However, its protective effect from sepsis-induced spleen damage is unknown. In this research, we established a mouse sepsis model induced by lipopolysaccharide (LPS) and investigated the protective effects of LIE on sepsis spleen injury in terms of inflammatory response, oxidative stress, and apoptosis.

• Authors: Hanyu Wang, Yuanhao Yang, Xiao Zhang, Yan Wang, Hui Fan, Jinfeng Shi, Xuelian Tan, Baoshi Xu, Jingchao Qiang, Enzhuang Pan, Mingyi Chu, Zibo Dong, Jingquan Dong
• Journal: Journal of Zhejiang University. Science. B (J Zhejiang Univ Sci B) Vol. 24 Issue 2 Pg. 185-190 (Feb 15 2023) ISSN: 1862-1783 [Electronic] China
• Vernacular Title: 莲心碱可减轻LPS诱导的小鼠脓毒症模型中脾脏组织炎症和氧化应激反应.
• PMID: 36751703 (Publication Type: Journal Article)

Chemical References

• liensinine
• Lipopolysaccharides

Topics

• Mice
• Animals
• Lipopolysaccharides (pharmacology)
• Spleen
• Inflammation
• Apoptosis
• Sepsis
• Oxidative Stress