Abstract | Objectives: Methods: At baseline, we studied the effects of high-frequency VIM stimulation and low-frequency stimulation of subthalamic projections on tremor and ataxia. The patient then adopted the best individual high-frequency stimulation programme at daytime and either 30 Hz-stimulation of the subthalamic contacts or StimOFF at night during two separate 5-weeks follow-up intervals. Both patient and rater were blinded to the stimulation settings. Results: High-frequency stimulation of the VIM effectively attenuated tremor. At follow-up, intermittent 30 Hz-stimulation at night resulted in a superior tremor response compared to StimOFF at night. Ataxia was not affected. Discussion: Stimulation of the VIM and adjacent subthalamic projections effectively attenuated tremor in a patient with confirmed SCA 27. Cycling between daytime high-frequency and night-time low-frequency stimulation led to a more sustained tremor response. This suggests to study in future if low-frequency stimulation of the subthalamic projection fibers may help overcome tolerance of tremor that is observed as a long-term limitation of VIM-DBS.
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Authors | Moritz A Loeffler, Matthis Synofzik, Idil Cebi, Philipp Klocke, Mohammad Hormozi, Thomas Gasser, Alireza Gharabaghi, Daniel Weiss |
Journal | Frontiers in neurology
(Front Neurol)
Vol. 13
Pg. 1048530
( 2022)
ISSN: 1664-2295 [Print] Switzerland |
PMID | 36588880
(Publication Type: Case Reports)
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Copyright | Copyright © 2022 Loeffler, Synofzik, Cebi, Klocke, Hormozi, Gasser, Gharabaghi and Weiss. |