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Effect of Tauroursodeoxycholic Acid on Inflammation after Ocular Alkali Burn.

Abstract
Inflammation is the main cause of corneal and retinal damage in an ocular alkali burn (OAB). The aim of this study was to investigate the effect of tauroursodeoxycholic acid (TUDCA) on ocular inflammation in a mouse model of an OAB. An OAB was induced in C57BL/6j mouse corneas by using 1 M NaOH. TUDCA (400 mg/kg) or PBS was injected intraperitoneally (IP) once a day for 3 days prior to establishing the OAB model. A single injection of Infliximab (6.25 mg/kg) was administered IP immediately after the OAB. The TUDCA suppressed the infiltration of the CD45-positive cells and decreased the mRNA and protein levels of the upregulated TNF-α and IL-1β in the cornea and retina of the OAB. Furthermore, the TUDCA treatment inhibited the retinal glial activation after an OAB. The TUDCA treatment not only ameliorated CNV and promoted corneal re-epithelization but also attenuated the RGC apoptosis and preserved the retinal structure after the OAB. Finally, the TUDCA reduced the expression of the endoplasmic reticulum (ER) stress molecules, IRE1, GRP78 and CHOP, in the retinal tissues of the OAB mice. The present study demonstrated that the TUDCA inhibits ocular inflammation and protects the cornea and retina from injury in an OAB mouse model. These results provide a potential therapeutic intervention for the treatment of an OAB.
AuthorsYanqiao Huang, Lixia Lin, Yao Yang, Fang Duan, Miner Yuan, Bingsheng Lou, Xiaofeng Lin
JournalInternational journal of molecular sciences (Int J Mol Sci) Vol. 23 Issue 19 (Oct 03 2022) ISSN: 1422-0067 [Electronic] Switzerland
PMID36233018 (Publication Type: Journal Article)
Chemical References
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha
  • Taurochenodeoxycholic Acid
  • Sodium Hydroxide
  • ursodoxicoltaurine
  • Infliximab
  • Protein Serine-Threonine Kinases
Topics
  • Animals
  • Apoptosis
  • Burns, Chemical (drug therapy)
  • Disease Models, Animal
  • Endoplasmic Reticulum Stress
  • Inflammation (drug therapy)
  • Infliximab (therapeutic use)
  • Mice
  • Mice, Inbred C57BL
  • Protein Serine-Threonine Kinases
  • RNA, Messenger
  • Sodium Hydroxide (pharmacology)
  • Taurochenodeoxycholic Acid (pharmacology, therapeutic use)
  • Tumor Necrosis Factor-alpha (metabolism)

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