Roles of Non-Coding RNAs in Virus-Host Interaction About Pathogenesis of Hand-Foot-Mouth Disease.

Abstract

Noncoding RNAs (ncRNAs) represent the largest and main transcriptome products and play various roles in the biological activity of cells and pathological processes. Accumulating evidence shows that microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) are important ncRNAs that play vital regulatory roles during viral infection. Hand-foot-mouth disease (HFMD) virus causes hand-foot-mouth disease, and is also associated with various serious complications and high mortality. However, there is currently no effective treatment. In this review, we focus on advances in the understanding of the modulatory role of ncRNAs during HFMD virus infection. Specifically, we discuss the generation, classification, and regulatory mechanisms of miRNA, lncRNA, and circRNA in the interaction between virus and host, with a particular focus on their influence with viral replication and infection. Analysis of these underlying mechanisms can help provide a foundation for the development of ncRNA-based antiviral therapies.

• Authors: Wei Chen, Jinwei Li, Jing Li, Jiayu Zhang, Jihong Zhang
• Journal: Current microbiology (Curr Microbiol) Vol. 79 Issue 9 Pg. 247 (Jul 14 2022) ISSN: 1432-0991 [Electronic] United States
• PMID: 35834056 (Publication Type: Journal Article, Review)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• MicroRNAs
• RNA, Circular
• RNA, Long Noncoding
• RNA, Untranslated

Topics

• Hand, Foot and Mouth Disease (genetics, virology)
• Host Microbial Interactions (genetics)
• Humans
• MicroRNAs (genetics)
• RNA, Circular
• RNA, Long Noncoding (genetics)
• RNA, Untranslated (genetics)
• Viruses (genetics)