De novo neuroendocrine features in prostate cancer.

Abstract

Neuroendocrine tumors of the prostate are rare and encompass a group of entities that are classified based on a combination of morphological and immunohistochemical features. Despite the 2016 World Health Organization classification of prostatic neuroendocrine tumors, variants have been reported that do not fit well in the categorization scheme. While the majority of these tumors arise in the setting of castration-resistant prostate cancer (postandrogen deprivation therapy), de novo cases may occur. In this review, we highlight the most significant pathological and immunohistochemical features, emerging biomarkers, and molecular features of such tumors.

• Authors: Eman Abdulfatah, Samson W Fine, Tamara L Lotan, Rohit Mehra
• Journal: Human pathology (Hum Pathol) Vol. 127 Pg. 112-122 (09 2022) ISSN: 1532-8392 [Electronic] United States
• PMID: 35810832 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022. Published by Elsevier Inc.

Topics

• Carcinoma, Neuroendocrine (pathology, therapy)
• Humans
• Male
• Neuroendocrine Tumors (pathology)
• Prostate (pathology)
• Prostatic Neoplasms (pathology)
• Prostatic Neoplasms, Castration-Resistant (pathology)