Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed Streptococcus thermophilus MN-ZLW-002.

Abstract

In this study, C57BL/6J male mice were fed normal chow (NC; control) or a high-fat diet (HFD) for 12 weeks, and HFD mice were supplemented with oral administration of Streptococcus thermophilus MN-ZLW-002 (HFD + MN002); n=20/group. Body weight, visceral fat, blood glucose, blood lipids and liver lipid deposition increased in the HFD group, and the composition of gut microbiota, cecum short-chain fatty acids and fecal bile acids (BAs) also changed. Oral-fed MN-002 increased the relative abundances of Ruminococcaceae, Lachnospiraceae and Streptococcaceae and improved blood glucose, liver cholesterol deposition, and serum IL-10, CCL-3 and the fecal BAs composition. In conclusion, the high-fat diet changed the composition of bile acids by shaping the gut microbiota into an obese type, leading to metabolic disturbances. Streptococcus thermophilus MN-ZLW-002 regulated gut microbiota by adjusting the composition of bile acids and improved the perturbation caused by high-fat diets. However, the effect of MN002 observed in animal experiments needs to be verified by long-term clinical trials.

• Authors: Yating Luo, Ruyue Cheng, Huijing Liang, Zhonghua Miao, Jiani Wang, Qingqing Zhou, Jianguo Chen, Fang He, Xi Shen
• Journal: Experimental animals (Exp Anim) Vol. 71 Issue 4 Pg. 468-480 (Nov 10 2022) ISSN: 1881-7122 [Electronic] Japan
• PMID: 35793979 (Publication Type: Journal Article)

Chemical References

• Bile Acids and Salts
• Blood Glucose

Topics

• Male
• Mice
• Animals
• Diet, High-Fat (adverse effects)
• Streptococcus thermophilus
• Mice, Inbred C57BL
• Lipid Metabolism
• Bile Acids and Salts (metabolism)
• Liver (metabolism)
• Blood Glucose (metabolism)