Obesity is one of the
circadian rhythm disorders (CRD)-mediated metabolic disorder syndromes. Pu-erh
tea is a viable dietary intervention for CRD, however its effect on CRD-induced
obesity is unclear. Here, we found that Pu-erh
tea improved
obesity in CRD-induced mice, which stemmed from the production of
Cinnabarinic acid (CA). CA promoted adipose tissue lipolysis and thermogenic response (HSL, ATGL, PparĪ±, CKB, UCP1) and increased adipocyte sensitivity to
hormones and
neurotransmitters by targeting the expression of adipose tissue receptor
proteins (Q6KAT8, P51655, A2AKQ0, M0QWX7, Q6ZQ33, and
mGluR4). This improved mitochondrial activity and facilitated adipose tissue metabolic processes, thereby accelerating glucolipid metabolism. Also, CA-induced alterations in gut microbes and
short-chain fatty acids further improved CRD-mediated
lipid accumulation. These results suggest that the increase of CA caused by Pu-erh
tea, targeted to adipose tissue via the metabolite-blood circulation-adipose tissue axis, maybe a key mechanism for reducing the development of CRD-induced
obesity.