Abstract |
MATERIALS AND METHODS: The animals were divided into six groups: (1) Control; (2) propylthiouracil (PTU), (3) PTU-POG 10, (4) PTU-POG 20, (5) PTU-RSG 2, and (6) PTU-RSG 4. Hypothyroidism was induced in rats by giving 0.05% propylthiouracil (PTU) in drinking water for 42 days. The rats of PTU-POG 10 and PTU-POG 20 groups received 10 and 20 mg/kg POG, respectively, besides PTU, and the rats of PTU-RSG 2 and PTU-RSG 4 groups received 2 and 4 mg/kg RSG, respectively, besides PTU. The animals were sacrificed, and the serum of the rats was collected to measure thyroxine level. The heart and aorta tissues were also removed for the measurement of biochemical oxidative stress markers. RESULTS:
Hypothyroidism was induced by PTU administration, which was indicated by lower serum thyroxine levels. Hypothyroidism also was accompanied by a decrease of catalase (CAT), superoxide dismutase (SOD) activities, and thiol concentration in the heart and aorta tissues while increased level of malondialdehyde (MDA). Interestingly, administration of POG or RSG dramatically reduced oxidative damage in the heart and aorta, as reflected by a decrease in MDA and increased activities of SOD, CAT, and thiol content. CONCLUSION: The results of this study showed that administration of POG or RSG decreased oxidative damage in the heart and aorta tissues induced by hypothyroidism in rats.
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Authors | Yousef Baghcheghi, Farimah Beheshti, Mahmoud Hosseini, Arezoo Gowhari-Shabgah, Mohammad Ali-Hassanzadeh, Mahdiyeh Hedayati-Moghadam |
Journal | Clinical and experimental hypertension (New York, N.Y. : 1993)
(Clin Exp Hypertens)
Vol. 44
Issue 6
Pg. 539-547
(Aug 18 2022)
ISSN: 1525-6006 [Electronic] England |
PMID | 35722928
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- PPAR gamma
- Sulfhydryl Compounds
- Propylthiouracil
- Superoxide Dismutase
- Thyroxine
- Pioglitazone
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Heart
- Hypothyroidism
(chemically induced, complications, drug therapy)
- Oxidative Stress
- PPAR gamma
- Pioglitazone
(pharmacology)
- Propylthiouracil
(adverse effects)
- Rats
- Rats, Wistar
- Sulfhydryl Compounds
- Superoxide Dismutase
(metabolism)
- Thyroxine
(adverse effects)
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