In past researches, we had been proved the action mechanism of pre-germinated brown rice (PGBR) to treat
metabolic syndrome and
diabetes mellitus. This study was to investigate the protective effect of PGBR in high
fructose and high fat-induced
non-alcoholic fatty liver disease (
NAFLD) in rodents. WKY rats were divided into: Control group was fed normal
drinking water and diet; FLD group was fed 10% high-
fructose-water (HFW) and high-fat-diet (HFD); PGBR group was given HFW, and HFD mixed PGBR. After four weeks, the body, hepatic and cardiac
weight gains of FLD group had significant increases than that of Control group. The enhanced blood pressure and heart rate,
hypertriglyceridemia,
hyperuricemia, and higher liver function index (GPT levels) were observed; meanwhile, the
IL-6 and TNF-α levels of serum, and TG level of liver were also elevated in FLD group. The related
protein expressions of
lipid synthesis,
inflammation, cardiac
fibrosis, and
hypertrophy were deteriorated by HFW/HFD. However, in treatment group, PGBR decreased all above influenced parameters, additionally GOT; and related
protein expressions. PGBR treated HFW/HFD-induced
NAFLD and cardiac complications might be via improving
lipid homeostasis, and inhibiting
inflammation. Together, PGBR could be used as a healthy food for controlling
NAFLD and its' cardiac dysfunction.