Abstract | INTRODUCTION: OBJECTIVE: DESIGN, SETTING AND PARTICIPANTS: Retrospective analysis of patients who had a stroke admitted at the rehabilitation facility in Changi General Hospital, Singapore, between June 2008 and May 2017, with median follow-up of 141 (95% CI 120 to 163) months. OUTCOME MEASURES AND RESULTS OF UNIVARIATE ANALYSIS: Total 681 patients, median age (63.6) years, 173 (28%) died during follow-up. Elevated blood urea (3.02, 95% CI 2.17 to 4.22; p≤0.001) and creatinine (1.96, 95% CI 1.50 to 2.57; p≤0.001) during stroke affected survival adversely.Excluding patients with CKD, we analysed the remaining 617 patients. AKI was noted in 75 (12.15%) patients during the index admission, and it affected survival adversely (2.16, 95% CI 1.49 to 3.13; p<0.001). Of the patients with AKI, 21 of 75 (28%) progressed to CKD over a median follow-up of 40.7 months. CONCLUSIONS: We found AKI during stroke admission was associated with increased mortality as compared with those without AKI on univariate analysis. AKI without need of renal replacement therapy was also associated with progression to CKD in this cohort. This suggests that patients with AKI need to have their renal function monitored longitudinally for development of CKD.
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Authors | Shrikant D Pande, Debajyoti Roy, Aye Aye Khine, May M Win, Lorecar Lolong, Ni Thu Shan, Pei Ting Tan, Tian Ming Tu |
Journal | BMJ open
(BMJ Open)
Vol. 12
Issue 5
Pg. e050743
(05 25 2022)
ISSN: 2044-6055 [Electronic] England |
PMID | 35613807
(Publication Type: Journal Article)
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Copyright | © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Topics |
- Acute Kidney Injury
(epidemiology, etiology)
- Humans
- Incidence
- Middle Aged
- Renal Dialysis
(adverse effects)
- Renal Insufficiency, Chronic
(complications)
- Retrospective Studies
- Risk Factors
- Stroke
(complications, epidemiology)
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