Abstract | Background: Major depression is one of the most disabling health conditions internationally. In recent years, new generation antidepressant medicines have become very widely prescribed. While these medicines are efficacious, side effects are common and frequently result in discontinuation of treatment. Compared with specific pharmacological properties of the different medications, the relevance of individual vulnerability is understudied. Methods: We used data from the Australian Genetics of Depression Study to gain insights into the aetiology and genetic risk factors to antidepressant side effects. To this end, we employed structural equation modelling, polygenic risk scoring and regressions. Results: Conclusions: Our results suggest a set of common factors underlying the risk for antidepressant side effects. These factors seem to be partly explained by genetic liability related to depression severity and the nature of the side effect. Future studies on the genetic aetiology of side effects will enable insights into their underlying mechanisms and the possibility of risk stratification and prophylaxis strategies.
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Authors | Adrian I Campos, Aoibhe Mulcahy, Jackson G Thorp, Naomi R Wray, Enda M Byrne, Penelope A Lind, Sarah E Medland, Nicholas G Martin, Ian B Hickie, Miguel E Rentería |
Journal | Communications medicine
(Commun Med (Lond))
Vol. 1
Pg. 45
( 2021)
ISSN: 2730-664X [Electronic] England |
PMID | 35602235
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2021. |