Abstract | BACKGROUND: METHODS: Sixty hypertensive patients with heart failure with a moderately reduced ejec-tion fraction were randomly divided into cardiac rehabilitation group and positive control group with 30 cases per group, while 30 hypertensive patients without heart failure were recruited as negative control group. The cardiac rehabilitation group and positive control group were treated with 1-month cardiac rehabilitation combined with the routine treat-ment and routine treatment only, respectively. The New York Heart Association classi-fication, 6-minute walking test, and color Doppler echocardiography were adopted to detect cardiac function. Meanwhile, the expression of microRNA-423-5p and N-terminal pro- B-type natriuretic peptide was determined via Real-Time Fluorescence Quantitative PCR and electrochemiluminescence immunoassay. The diagnostic potential of microR- 423-5p and N-terminal pro- B-type natriuretic peptide was assessed by ROC curve analy- sis and multivariate linear regression model. RESULTS: Patients in cardiac rehabilitation group displayed significantly lower expression of microR-423-5p and better results of New York Heart Association classification, 6-min-ute walking test, and color Doppler echocardiography than those in positive controlgroup (P < .05). ROC analysis showed that microR-423-5p (AUC = 0.785; 95% CI: 0.686- 0.865; sensitivity = 73.33%; specificity = 73.33%) had better specificity and accuracy thanN-terminal pro- B-type natriuretic peptide (AUC=0.721; 95% CI: 0.617-0.811; sensitiv- ity = 81.67%; specificity = 63.33%). CONCLUSION:
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Authors | Ying Huang, Yun Zhang, Wenzheng Nong, Biyang Lan, Dingmin Zhang |
Journal | Anatolian journal of cardiology
(Anatol J Cardiol)
Vol. 26
Issue 5
Pg. 366-372
(05 2022)
ISSN: 2149-2271 [Electronic] Turkey |
PMID | 35552172
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Biomarkers
- Circulating MicroRNA
- MIRN423 microRNA, human
- MicroRNAs
- Peptide Fragments
- Natriuretic Peptide, Brain
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Topics |
- Biomarkers
- Cardiac Rehabilitation
- Circulating MicroRNA
- Heart Failure
(complications)
- Humans
- Hypertension
(complications)
- MicroRNAs
- Natriuretic Peptide, Brain
- Peptide Fragments
- Stroke Volume
- Ventricular Function, Left
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