A highly selective and sensitive spectrofluorimetric method for the assessment of 3-nitrotyrosine in serum using (Eu(TTA)3Phen) photo probe.

Abstract

A simple, accurate and fast method was developed for the assessment of 3-nitrotyrosine as a biomarker for the early diagnosis of liver cirrhosis with minimal hepatic encephalopathy (MHE) using a (Eu(TTA)3Phen) photo probe. 3-Nitrotyrosine can remarkably quench the luminescence intensity of the (Eu(TTA)3Phen) complex in DMSO at pH = 9 and λ em = 617 nm. The quenching of the luminescence intensity of (Eu(TTA)3Phen) complex particularly the electrical emission band at λ em = 617 nm is used for the assessment of 3-nitrotyrosine in different serum samples of patients with liver cirrhosis.

• Authors: Mohmed S Attia, Ahmed O Youssef, Nour A Abdel-Sattar, Mohammed A Amin, Sarah Alharthi, Ekram H Mohamed, Safwat A Mahmoud, Mona N Abou-Omar
• Journal: RSC advances (RSC Adv) Vol. 12 Issue 8 Pg. 4536-4542 (Feb 03 2022) ISSN: 2046-2069 [Electronic] England
• PMID: 35425515 (Publication Type: Journal Article)
• Copyright: This journal is © The Royal Society of Chemistry.