Long non-coding RNAs (lncRNAs) are non-coding RNAs that have more than 200
nucleotides and can participate in the regulation of gene expression in various ways. An increasing number of studies have shown that the dysregulated expression of lncRNAs is related to the occurrence and progression of human
cancers. LINC00665 is a novel
lncRNA, which is abnormally expressed in various human
cancers, such as
lung cancer,
breast cancer,
prostate cancer, and
glioma. LINC00665 functions in many biological processes of
tumor cells, such as cell proliferation, migration, invasion, angiogenesis, and metabolism, and is related to the clinicopathological characteristics of
cancer patients. LINC00665 can play biological functions as a
ceRNA, directly binding and interacting with
proteins, and as an upstream molecule regulating multiple signaling pathways. In this review, we comprehensively summarize the expression level, function, and molecular mechanisms of LINC00665 in different human
cancers and emphasize that LINC00665 is a promising new diagnostic, prognostic
biomarker, and therapeutic target.