Abstract | BACKGROUND: INTRODUCTION: METHODS: RESULTS: Clinical adverse effects such as tremors (facial and generalized), bruxism, nystagmus, mydriasis, and vocalization were presented in all the medetomidine/ opioid treatments. Clinical adverse effects were observed at 10-90 minutes in medetomidine/ opioid treatments. Animals in all treatments were sedated at 5-90 minutes. Sedation was significantly higher in medetomidine/ opioid treatments than in medetomidine at 15-30 minutes after administration (P < 0.05). In all treatments, heart rate and respiratory rate significantly decreased from baseline at 5-105 and 30-60 minutes, respectively. There was no significant difference in heart and respiratory rates between different treatments at any time point. Ruminal motility was decreased in medetomidine and medetomidine/ opioid treatments at 10-75 and 10-105 minutes, respectively. Compared with medetomidine, ruminal motility was significantly lower in medetomidine/ opioid treatments at 75-105 minutes. CONCLUSION: The use of combinations of medetomidine/ opioids would be considered for superior sedation at 15-30 minutes after administration in goats. No significant differences were detected among opioids in combination with medetomidine in goats.
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Authors | Maryam Salarpour, Ehsanollah Sakhaee, Amir Saeed Samimi, Omid Azari |
Journal | Veterinary medicine and science
(Vet Med Sci)
Vol. 8
Issue 4
Pg. 1664-1670
(07 2022)
ISSN: 2053-1095 [Electronic] England |
PMID | 35353952
(Publication Type: Journal Article)
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Copyright | © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. |
Chemical References |
- Analgesics, Opioid
- Hypnotics and Sedatives
- Tramadol
- Morphine
- Meperidine
- Medetomidine
- Methadone
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Topics |
- Analgesics, Opioid
(pharmacology)
- Animals
- Goats
- Hypnotics and Sedatives
(pharmacology)
- Medetomidine
(pharmacology)
- Meperidine
- Methadone
(pharmacology)
- Morphine
(pharmacology)
- Tramadol
(pharmacology)
|