Gelatin-glucosamine hydrochloride/crosslinked-cyclodextrin metal-organic frameworks@IBU composite hydrogel long-term sustained drug delivery system for osteoarthritis treatment.

Abstract

Osteoarthritis (OA) is a disease of articular cartilage degradation and inflammation of the joint capsule. Combining anti-inflammatory therapy with nutritional supplement is an effective means for the treatment of OA. In this study, we prepared gelatin (Gel)-glucosamine hydrochloride (GH) mixed crosslinked-cyclodextrin metal-organic framework (G-GH/CL-CD-MOF) composite hydrogel. Polyethylene glycol diglycidyl ether was the crosslinking agent of GH and Gel to solve the problem of poor mechanical properties and water solubility at 37 °C. CL-CD-MOF was fabricated through a simple one-step chemical reaction to crosslink the hydrophilic hydroxyl groups in CD-MOF with diphenyl carbonate. Electron microscopy and x-ray diffraction analysis of CL-CD-MOF showed perfect porous morphology with a chaotic internal structure. CL-CD-MOF@IBU was prepared by immersing CL-CD-MOF in high-concentration ibuprofen (IBU) solution. CL-CD-MOF@IBU was uniformly dispersed in Gel and GH mixed solution to prepare G-GH/CL-CD-MOF@IBU composite hydrogel long-term sustained drug delivery system. The compression curve of G-GH/CL-CD-MOF composite hydrogel showed a non-linear elastic behavior. The cyclic loading-unloading compression showed that the shape of the G-GH/CL-CD-MOF composite hydrogel can be kept intact under 50% strain. On the day 14, the G-GH/CL-CD-MOF@IBU composite hydrogel was degraded by 87.1%, 61% of IBU was released. G-GH/CL-CD-MOF@IBU exhibited good biocompatibility during co-culture with MC3T3-E1 cells. Briefly, the certain mechanical properties, sustained drug release behavior, and good biocompatibility of G-GH/CL-CD-MOF@IBU composite hydrogel showed that it has potential application in OA treatment of long-term sustained nutritional supplement and anti-inflammatory synchronously.

• Authors: Hui Yang, Yinchun Hu, Min Kang, Huixiu Ding, Yue Gong, Xiangfei Yin, Ruize Sun, Yuhong Qin, Yan Wei, Di Huang
• Journal: Biomedical materials (Bristol, England) (Biomed Mater) Vol. 17 Issue 3 (04 11 2022) ISSN: 1748-605X [Electronic] England
• PMID: 35349993 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 IOP Publishing Ltd.

Chemical References

• Cyclodextrins
• Hydrogels
• Metal-Organic Frameworks
• Gelatin
• Glucosamine
• Ibuprofen

Topics

• Cyclodextrins
• Drug Delivery Systems
• Gelatin (chemistry)
• Glucosamine
• Humans
• Hydrogels
• Ibuprofen (chemistry)
• Metal-Organic Frameworks (chemistry)
• Osteoarthritis (drug therapy)