Abstract | BACKGROUND: METHODS: PubMed, EMBASE, and the Cochrane Library were searched for relevant studies. Effectiveness outcomes were weight loss, remission of comorbidities, and improvement in liver function. Safety outcomes were procedural complications and mortality. RESULTS: A total of 15 studies were included in this meta-analysis. Patients with compensated cirrhosis lost weight significantly after surgery, and the percentage of excess weight loss was 60.44 (95% CI, 44.34 to 76.55). Bariatric surgery resulted in remission of NAFLD in 57.9% (95% CI, 27.5% to 88.3%), T2DM in 58.4% (95% CI, 48.4% to 68.4%), hypertension in 53.1% (95% CI, 43% to 63.3%), dyslipidemia in 59.8% (95% CI, 41.1% to 78.5%) of patients with cirrhosis. Bariatric surgery reduced the levels of alanine aminotransferase and aspartate aminotransferase. The incidence of surgical complications in patients with cirrhosis was about 19.2% (95% CI, 11.7% to 26.6%), which was higher than that in patients without cirrhosis (OR 2.67 [95% CI, 1.26 to 5.67]). Patients with cirrhosis had an overall mortality rate of 1.3%, and the mortality rates for compensated cirrhosis and decompensated cirrhosis were 0.9% and 18.2%, respectively. CONCLUSIONS:
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Authors | Jie Bai, Zhe Jia, Yu Chen, Yongguo Li, Sujun Zheng, Zhongping Duan |
Journal | World journal of surgery
(World J Surg)
Vol. 46
Issue 5
Pg. 1122-1133
(05 2022)
ISSN: 1432-2323 [Electronic] United States |
PMID | 35275232
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s) under exclusive licence to Société Internationale de Chirurgie. |
Topics |
- Bariatric Surgery
(adverse effects, methods)
- Humans
- Liver Cirrhosis
(complications, surgery)
- Non-alcoholic Fatty Liver Disease
(complications)
- Obesity
(complications, surgery)
- Obesity, Morbid
(surgery)
- Weight Loss
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