Breast cancer is the most common malignant
tumor in women. Researchers have found that the combined use of multiple methods to treat
tumors is a promising strategy. Here, we have developed a biomimetic nano-platform PDA@MB for
tumor targeted
photothermal therapy (PTT) combined with
chemotherapy. The 4T1 cell membrane loaded with
cucurbitacin B (CuB) was used to coat
polydopamine (PDA) nanoparticles, which gave PDA@MB nanoparticles the ability to target
tumors and escape immune cells from phagocytosis. PDA@MB showed excellent photothermal performance including high photothermal conversion efficiency and photostability, and exhibited outstanding in vitro PTT effect under NIR
laser irradiation. The high temperature ruptured the PDA@MB membrane to release CuB, which changed the
tumor hypoxic environment, down-regulated the FAK/
MMP signaling pathway, and significantly inhibited the
metastasis and proliferation of
tumor cells. The results of in vivo experiments indicated that the
tumor growth of the 4T1 mouse
tumor model was significantly inhibited. Additionally, toxicity studies showed that PDA@MB had good biocompatibility and safety. In conclusion, this study provides a promising chemo-
photothermal therapy (
CPT) nano-platform for precise and effective
breast cancer therapy.