Abstract | OBJECTIVE: The purpose of this study was to investigate whether soy isoflavone supplementation is effective in preventing periodontal destruction exacerbated by estrogen deficiency (ED) and its potential mechanism. BACKGROUND: METHODS: RESULTS:
Estrogen deficiency impaired the expression of genes encoding tight junction proteins in the gingiva, increased IL-17 level, and accelerated alveolar bone resorption. SI treatment alleviated tight junction protein expression, decreased IL-17 and ROS levels, and prevented the absorption of alveolar bone. Furthermore, GRHL2 expression was significantly induced by SI in human oral keratinocytes-1 (HOK-1) cells; GRHL2 knockdown impaired the expression of OCLN and ZO-1 induced by SI treatment. CONCLUSION:
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Authors | Chengcheng Liu, Shengdan Zhang, Huimin Bai, Yuwei Zhang, Yixuan Jiang, Zhuo Yang, Xin Xu, Yi Ding |
Journal | Journal of periodontal research
(J Periodontal Res)
Vol. 57
Issue 3
Pg. 519-532
(Jun 2022)
ISSN: 1600-0765 [Electronic] United States |
PMID | 35212419
(Publication Type: Journal Article)
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Copyright | © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Estrogens
- Interleukin-17
- Isoflavones
- Reactive Oxygen Species
- Tight Junction Proteins
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Topics |
- Alveolar Bone Loss
(prevention & control)
- Animals
- Disease Models, Animal
- Estrogens
(therapeutic use)
- Female
- Humans
- Interleukin-17
- Isoflavones
(pharmacology, therapeutic use)
- Periodontitis
(drug therapy, metabolism, prevention & control)
- Rats
- Reactive Oxygen Species
- Tight Junction Proteins
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