Consensus statement by the French Society of Endocrinology (SFE) and French Society of Pediatric Endocrinology & Diabetology (SFEDP) on diagnosis of Cushing's syndrome.

Abstract

Cushing's syndrome is defined by prolonged exposure to glucocorticoids, leading to excess morbidity and mortality. Diagnosis of this rare pathology is difficult due to the low specificity of the clinical signs, the variable severity of the clinical presentation, and the difficulties of interpretation associated with the diagnostic methods. The present consensus paper by 38 experts of the French Society of Endocrinology and the French Society of Pediatric Endocrinology and Diabetology aimed firstly to detail the circumstances suggesting diagnosis and the biologic diagnosis tools and their interpretation for positive diagnosis and for etiologic diagnosis according to ACTH-independent and -dependent mechanisms. Secondly, situations making diagnosis complex (pregnancy, intense hypercortisolism, fluctuating Cushing's syndrome, pediatric forms and genetically determined forms) were detailed. Lastly, methods of surveillance and diagnosis of recurrence were dealt with in the final section.

• Authors: Antoine Tabarin, Guillaume Assié, Pascal Barat, Fidéline Bonnet, Jean François Bonneville, Françoise Borson-Chazot, Jérôme Bouligand, Anne Boulin, Thierry Brue, Philippe Caron, Frédéric Castinetti, Olivier Chabre, Philippe Chanson, Jean Benoit Corcuff, Christine Cortet, Régis Coutant, Anthony Dohan, Delphine Drui, Stéphanie Espiard, Delphine Gaye, Solenge Grunenwald, Laurence Guignat, Elif Hindie, Frédéric Illouz, Peter Kamenicky, Hervé Lefebvre, Agnès Linglart, Laetitia Martinerie, Marie Odile North, Marie Laure Raffin-Samson, Isabelle Raingeard, Gérald Raverot, Véronique Raverot, Yves Reznik, David Taieb, Delphine Vezzosi, Jacques Young, Jérôme Bertherat
• Journal: Annales d'endocrinologie (Ann Endocrinol (Paris)) Vol. 83 Issue 2 Pg. 119-141 (04 2022) ISSN: 2213-3941 [Electronic] France
• PMID: 35192845 (Publication Type: Review)
• Copyright: Copyright © 2022 Elsevier Masson SAS. All rights reserved.

Chemical References

• Glucocorticoids

Topics

• Child
• Consensus
• Cushing Syndrome (diagnosis, etiology)
• Endocrinology
• Female
• Glucocorticoids
• Humans
• Pregnancy