Novel insights into the roles and therapeutic implications of MUC1 oncoprotein via regulating proteins and non-coding RNAs in cancer.

Abstract

Mucin 1 (MUC1) is a heterodimeric transmembrane glycoprotein that protects epithelial cells in mammals. The transmembrane C-terminal subunit (MUC1-C) plays a crucial role in oncogenesis. As an oncoprotein, MUC1-C regulates a number of proteins that are associated with tumorigenesis by interacting with oncoproteins, transcription factors, coactivators, etc., inducing proliferation, epithelial-mesenchymal transition (EMT), invasion, stemness, immune evasion, and drug resistance. Moreover, MUC1-C modulates the expression of non-coding RNAs (ncRNAs), which further regulate carcinogenesis by directly binding to specific proteins. ncRNAs can also affect MUC1 protein expression by targeting the MUC1 mRNA 3' untranslated region (UTR). A series of ncRNAs can modulate cancer development by regulating MUC1-C. This review focuses on the interaction of MUC1-C with proteins and ncRNAs in cancer progression. We also summarize the recent advances in immunotherapy with a focus on therapeutic approaches based on MUC1-C and nanocarrier complexes for cancer treatment.

• Authors: Wei Li, Yineng Han, Chenmin Sun, Xue Li, Junhua Zheng, Jianping Che, Xudong Yao, Donald Kufe
• Journal: Theranostics (Theranostics) Vol. 12 Issue 3 Pg. 999-1011 ( 2022) ISSN: 1838-7640 [Electronic] Australia
• PMID: 35154471 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © The author(s).

Chemical References

• MicroRNAs
• Mucin-1
• Oncogene Proteins
• RNA, Untranslated

Topics

• Animals
• Cell Line, Tumor
• Epithelial-Mesenchymal Transition (genetics)
• Mammals (genetics, metabolism)
• MicroRNAs (metabolism)
• Mucin-1 (metabolism)
• Neoplasms (genetics, therapy)
• Oncogene Proteins
• RNA, Untranslated (genetics)