Association between systemic inflammatory response syndrome and hematoma expansion in intracerebral hemorrhage.

Abstract

BACKGROUND:

Hematoma expansion (HE) is a relatively common complication after intracerebral hemorrhage.

OBJECTIVES:

To explore the association between systemic inflammatory response syndrome (SIRS) and HE in patients with intracerebral hemorrhage (ICH).

MATERIAL AND METHODS:

From June 2013 to October 2020, the sociodemographic data and clinical data of 780 ICH patients were collected. The logistic regression analysis with odd ratios (ORs) and 95% confidence intervals (95% CIs) was performed to analyze the risk factors for HE in patients with ICH.

RESULTS:

Hematoma expansion occurred in 151 (19.36%) patients with ICH. Significant differences were presented between SIRS and HE (OR = 2.549, 95% CI: [1.497; 4.342], p = 0.0006). After adjusting the covariates, a further analysis showed that the respiratory rate >20 beats/min (OR = 3.436, 95% CI: [1.981; 5.960], p < 0.0001), white blood cell (WBC) > 12×109/L or WBC ≤ 4×109/L (OR = 2.489, 95% CI: [1.494; 4.149], p = 0.0005) increased the risk for HE in ICH patients. Our study also found that the significant differences between HE and non-HE patients in proportion of patients with history of diabetes mellitus, basal ganglia hemorrhage, hypothalamus hemorrhage and fasting blood glucose (all p < 0.05) (OR = 2.076, 95% CI: [1.274; 3.381], p = 0.0034), basal ganglia hemorrhage (OR = 2.512, 95% CI: [1.496; 4.218], p = 0.0005), hypothalamus hemorrhage (OR = 2.121, 95% CI: [1.007; 4.466], p = 0.0479), high C-reactive protein (CRP) (OR = 1.013, 95% CI: [1.002; 1.024], p = 0.0184), and hyperglycemia (OR = 1.099, 95% CI: [1.026; 1.178], p = 0.0074) were associated with an increased risk of HE in ICH patients.

CONCLUSIONS:

The SIRS is closely associated with the risk of HE. Respiratory rate >20 beats/min and WBC count >12(109/L) or ≤4(109/L) increased the risk for HE in ICH patients. These findings can help to achieve the early prevention of HE and improve the prognosis of ICH patients.

• Authors: Yu Zhu, Zhikai Xie, Jie Shen, Lihui Zhou, Zongchi Liu, Di Ye, Fan Wu, Sohaib Hasan Abdullah Ezzi, Zahraa Sh Hmood, Renya Zhan
• Journal: Advances in clinical and experimental medicine : official organ Wroclaw Medical University (Adv Clin Exp Med) Vol. 31 Issue 5 Pg. 489-498 (May 2022) ISSN: 1899-5276 [Print] Poland
• PMID: 35148572 (Publication Type: Journal Article)

Topics

• Basal Ganglia Hemorrhage (complications)
• Cerebral Hemorrhage (complications)
• Hematoma (complications)
• Humans
• Prognosis
• Retrospective Studies
• Systemic Inflammatory Response Syndrome (complications)