Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study.

Abstract

BACKGROUND:

Evidence is accumulating that liver sinusoidal endothelial cells are involved in the pathogenesis of non-alcoholic fatty liver disease. Previous studies have suggested that the endothelial biomarker soluble E-selectin (sE-selectin) is to an important extent liver-derived.

AIMS:

To study the relationship of intrahepatic lipid (IHL) content with sE-selectin at the population level.

METHODS:

This study was conducted in participants of The Maastricht Study (n = 1,634), a population-based cohort study enriched with patients with type 2 diabetes. We assessed the cross-sectional association between IHL content, quantified by MRI, and sE-selectin via multivariable regression with adjustment for age, sex, type 2 diabetes, educational level, BMI, Dutch Healthy Diet index, physical activity, and the Matsuda index.

RESULTS:

Standardized IHL content was associated with (log) sE-selectin (age-, sex- and type 2 diabetes-adjusted regression coefficient [B]: 0.048 [95%CI:0.038;0.058], p<0.001), even after full adjustment (B: 0.030 [0.019;0.042], p<0.001). Such an association was not observed for soluble vascular cell adhesion molecule 1 (sVCAM-1) levels.

CONCLUSION:

IHL content is an independent determinant of sE-selectin at the population level. These findings support further studies to unravel the involvement of liver sinusoidal endothelial cells in the different stages of non-alcoholic fatty liver disease and the specific role of E-selectin herein.

• Authors: Martijn C G J Brouwers, Nynke Simons, Marianne Eline Kooi, Rianneke de Ritter, Martien C J M van Dongen, Simone J P M Eussen, Otto Bekers, Jeroen Kooman, Marleen M J van Greevenbroek, Carla J H van der Kallen, Miranda T Schram, Nicolaas C Schaper, Casper G Schalkwijk, Coen D A Stehouwer
• Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver (Dig Liver Dis) Vol. 54 Issue 8 Pg. 1038-1043 (08 2022) ISSN: 1878-3562 [Electronic] Netherlands
• PMID: 35135742 (Publication Type: Journal Article)
• Copyright: Copyright © 2022. Published by Elsevier Ltd.

Chemical References

• E-Selectin
• Lipids
• Vascular Cell Adhesion Molecule-1
• Intercellular Adhesion Molecule-1

Topics

• Cohort Studies
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2
• E-Selectin
• Endothelial Cells
• Humans
• Intercellular Adhesion Molecule-1
• Lipids
• Non-alcoholic Fatty Liver Disease
• Vascular Cell Adhesion Molecule-1