Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation.

Abstract

Nuclear paraspeckle assembly transcript 1 (Neat1) located at chromosome 11 is a long non-coding RNA that is widely expressed in mammalian cell types, and which is overexpressed in several inflammation-related disorders. Inflammation implies a plethora of mutual interactions between both soluble factors and cells due to various stimuli including tissue injury. Although there is no doubt that inflammation is critically involved in multiple biological and pathological processes alike, the precise mechanisms being involved are still open for debate. In this context, the role of Neat1 as a regulator of inflammation, microglial activation, and lipid accumulation under various inflammatory conditions remains elusive. Herein, we review the regulation of Neat1 and how it modulates the expression of its target genes. Thereafter, we will review the impact of Neat1 on inflammation by activating or inhibiting various signaling pathways, such as microRNAs, AKT, TLR4, TRAF6, and NF-κB.

• Authors: Yongli Pan, Ting Wang, Zhiqiang Zhao, Wei Wei, Xinyu Yang, Xianbin Wang, Wenqiang Xin
• Journal: Journal of inflammation research (J Inflamm Res) Vol. 15 Pg. 557-571 ( 2022) ISSN: 1178-7031 [Print] New Zealand
• PMID: 35115805 (Publication Type: Journal Article, Review)
• Copyright: © 2022 Pan et al.