Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation.

Abstract

Transketolase (TKT) which is an important metabolic enzyme in the pentose phosphate pathway (PPP) participates in maintaining ribose 5-phosphate levels. TKT is necessary for maintaining cell growth. However, we found that in addition to this, TKT can also affect tumor progression through other ways. Our previous study indicate that TKT could promote the development of liver cancer by affecting bile acid metabolism. And in this study, we discovered that TKT expression was remarkably upregulated in colorectal cancer, abnormal high expression of TKT is associated with poor prognosis of colorectal cancer. Additionally, TKT promoted colorectal cancer cell growth and metastasis. Further study demonstrated that TKT interacted with GRP78 and promoted colorectal cancer cell glycolysis through increasing AKT phosphorylation, thereby enhancing colorectal cancer cell metastasis. Thus, TKT is expected to become an indicator for judging the prognosis of colorectal cancer, and provide a theoretical basis for drug development of new treatment targets for colorectal cancer.

• Authors: Minle Li, Xue Zhao, Hongmei Yong, Jian Xu, Pengfei Qu, Shuxi Qiao, Pingfu Hou, Zhongwei Li, Sufang Chu, Junnian Zheng, Jin Bai
• Journal: Cell death & disease (Cell Death Dis) Vol. 13 Issue 2 Pg. 99 (02 02 2022) ISSN: 2041-4889 [Electronic] England
• PMID: 35110545 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022. The Author(s).

Chemical References

• Endoplasmic Reticulum Chaperone BiP
• HSPA5 protein, human
• Transketolase
• Proto-Oncogene Proteins c-akt

Topics

• Cell Line, Tumor
• Cell Proliferation
• Colorectal Neoplasms (metabolism, pathology)
• Endoplasmic Reticulum Chaperone BiP (metabolism)
• Female
• Glycolysis
• Humans
• Male
• Middle Aged
• Neoplasm Metastasis
• Phosphorylation
• Prognosis
• Protein Binding
• Proto-Oncogene Proteins c-akt (metabolism)
• Transketolase (metabolism)