Abstract | INTRODUCTION: AREAS COVERED: The authors review the safety and efficacy of isavuconazole in the management of invasive aspergillosis based on the currently available evidence. The authors also report on the structure, mechanism of action, pharmacokinetic properties, in vitro and in vivo studies as well as clinical safety and efficacy reports of isavuconazole since its FDA approval. EXPERT OPINION:
Isavuconazole is non-inferior to voriconazole and is a safe, effective, and better tolerated option for the treatment of invasive aspergillosis. It offers several advantages over other antifungal agents, including having a better adverse event profile with respect to hepatotoxicity, neuro-visual toxicity, QTc prolongation, as well as a stable pharmacokinetic profile obviating the need for therapeutic drug monitoring. Further studies are needed to evaluate its performance in prophylaxis against invasive aspergillosis as well as in the treatment of aspergillosis in critically ill patients without underlying cancer or transplant.
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Authors | Geetha Sivasubramanian, Pranatharthi H Chandrasekar |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 23
Issue 5
Pg. 543-549
(Apr 2022)
ISSN: 1744-7666 [Electronic] England |
PMID | 35099351
(Publication Type: Journal Article)
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Chemical References |
- Antifungal Agents
- Nitriles
- Pyridines
- Triazoles
- isavuconazole
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Topics |
- Antifungal Agents
(adverse effects)
- Aspergillosis
(chemically induced, drug therapy)
- Delayed Diagnosis
- Humans
- Nitriles
(adverse effects)
- Pyridines
- Triazoles
(adverse effects)
- COVID-19 Drug Treatment
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