Abstract | OBJECTIVES: METHODS: A search of MEDLINE, EMBASE, and Cochrane was performed to identify original articles reporting the detection rate of [68 Ga]Ga- DOTA-SSA PET/MRI for liver metastasis in comparison with PET/CT. The pooled detection rates for liver metastasis on PET/MRI and PET/CT were calculated and compared using a restricted maximum likelihood estimation of random-effects model. The pooled added value of PET/MRI in comparison with PET/CT was calculated. Sensitivity analysis and subgroup analysis were performed to explore causes of study heterogeneity. RESULTS: In the six included studies (638 liver metastases), the pooled detection rates for liver metastasis on [68 Ga]Ga- DOTA-SSA PET/MRI and PET/CT were 93.5% (95% confidence interval [CI], 85.1-97.3%; I2 = 84.8%) and 76.8% (95% CI, 64.8-85.6%; I2 = 87.8%), respectively. PET/MRI had a significantly higher detection rate than PET/CT (p = 0.02), with 15.3% (95% CI, 8.0-27.4%) added value over PET/CT. After sensitivity analysis, the recalculated detection rates for liver metastasis were 94.8% (95% CI, 90.8-97.2%; I2 = 42.1%) for PET/MRI and 80.0% (95% CI, 65.3-89.5%; I2 = 90.0%) for PET/CT. The study location and the use of predefined imaging criteria for liver metastasis were associated with PET/MRI study heterogeneity. CONCLUSION: [68 Ga]Ga- DOTA-SSA PET/MRI had good overall performance for detecting liver metastasis in patients with NET. Because of the small number of eligible studies, further studies are needed to validate the clinical usefulness of [68 Ga]Ga- DOTA-SSA PET/MRI. KEY POINTS: • [68 Ga]Ga- DOTA-SSA PET/MRI had a higher pooled detection rate for liver metastasis than PET/CT (93.5% vs. 76.8%). • The added value of [68 Ga]Ga- DOTA-SSA PET/MRI for detecting liver metastasis in comparison with PET/CT was 15.3%. •Study location and the predefined imaging criteria for liver metastasis were significant factors causing PET/MRI study heterogeneity.
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Authors | Se Jin Choi, Sang Hyun Choi, Dong Yun Lee, Ji Sung Lee, Dong Wook Kim, Jong Keon Jang |
Journal | European radiology
(Eur Radiol)
Vol. 32
Issue 7
Pg. 4628-4637
(Jul 2022)
ISSN: 1432-1084 [Electronic] Germany |
PMID | 35092473
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | © 2022. The Author(s), under exclusive licence to European Society of Radiology. |
Chemical References |
- Heterocyclic Compounds, 1-Ring
- Organometallic Compounds
- 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
- Somatostatin
|
Topics |
- Heterocyclic Compounds, 1-Ring
- Humans
- Liver Neoplasms
(diagnostic imaging)
- Magnetic Resonance Imaging
- Neuroendocrine Tumors
(diagnostic imaging, pathology)
- Organometallic Compounds
- Positron Emission Tomography Computed Tomography
(methods)
- Positron-Emission Tomography
(methods)
- Somatostatin
|