Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: Cel gel targeted the Langerhans cells. In IMQ-induced psoriatic dermatitis, Cel gel reduced the secretion of interleukin (IL)- 23 by Langerhans cells, suppressed the interaction between Langerhans cells and γδT cells, and decreased the number of activated γδT cells and related IL-17 secretion, alleviating psoriasis-like inflammation. Furthermore, Cel gel demonstrated a glucocorticoid-like effect that could impede the recurrence of psoriasis. CONCLUSION: Cel gel reduces the secretion of IL-23 from LCs and inhibits the interaction between LCs and γδT cells to alleviate psoriasis. It also shows an effect similar to that of glucocorticoids, which can prevent psoriasis recurrence. These findings provide a new direction for the clinical treatment of psoriasis and contribute to the development of novel drugs.
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Authors | Liu Liu, Xi Chen, Yi Lu, Xiao-Ying Sun, Kan Ze, Ya-Qiong Zhou, Wei Li, Xin Li, Hong-Jin Li, Bin Li |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 147
Pg. 112644
(Mar 2022)
ISSN: 1950-6007 [Electronic] France |
PMID | 35051865
(Publication Type: Journal Article)
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Copyright | Copyright © 2022. Published by Elsevier Masson SAS. |
Chemical References |
- Gels
- Interleukin-23
- Pentacyclic Triterpenes
- celastrol
- Imiquimod
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Topics |
- Animals
- Disease Models, Animal
- Female
- Gels
- Imiquimod
(pharmacology)
- Interleukin-23
(metabolism)
- Langerhans Cells
(drug effects)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Pentacyclic Triterpenes
(pharmacology)
- Psoriasis
(pathology)
- Tripterygium
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