Cardiac valve calcification is highly prevalent in patients with
chronic kidney disease (CKD). Low
vitamin D levels are associated with
vascular calcification in CKD. However, the association between
vitamin D levels and cardiac valve calcification is unknown. A total of 513 patients with pre-dialysis CKD were included in this cross-sectional study. Aortic valve calcification (AVC) and mitral valve calcification (MVC) were assessed using two-dimensional echocardiography. The associations between AVC and MVC and baseline variables were investigated using logistic regression analyses. In multivariable analysis, serum 1,25(
OH)2D level was independently associated with AVC (odds ratio [OR], 0.87; P < 0.001) and MVC (OR, 0.92; P < 0.001). Additionally, age, diabetes,
coronary heart disease, calcium × phosphate product, and intact
parathyroid hormone levels were independently associated with AVC and MVC. Systolic blood pressure was independently associated with AVC. A receiver-operating characteristic (ROC) curve analysis showed that the best cutoff values of serum 1,25(
OH)2D levels for predicting AVC and MVC were ≤ 12.5 and ≤ 11.9 pg/dl, respectively. Serum 1,25(
OH)2D deficiency is independently associated with AVC and MVC in patients with CKD, suggesting that serum 1,25(
OH)2D level may be a potential
biomarker of AVC and MVC in these patients.