Ganoderma modulates allergic asthma pathologic features via anti-inflammatory effects.

Abstract

Ganoderma, a fungal genus, is a traditional medicine with immuno-modulating effects. Asthma is an inflammatory disease of airways, and the main trigger of asthma is allergic inflammation. In this study, the effects of Ganoderma (an anti-inflammatory agent) given via oral administration (G/O) or intraperitoneal injection (G/IP) on asthma was evaluated. Forty BALB/c mice were divided into four groups, including the control, OVA-challenge, OVA-challenge + G/O, and OVA-challenge + G/IP. To determine AHR, the MCh challenge test was done. The levels of IL-1β, -4, -5, -6, -8, -10, -12, -13, -17, -25, -33, -38, Cys-LT, LTB4, and hydroxyproline were measured. Finally, lung histopathology was evaluated to determine eosinophilic inflammation, goblet cell hyperplasia, and mucus hyper-secretion. Treatment with G/O and G/IP could significantly reduce the levels of IL-1β, -5, -6, -8, -17, -25, -33, and -38; the levels of IL-4 and IL-13 had no significant changes, but the levels of IL-10 and IL-12 were enhanced. The mice treated with G/O and G/IP showed decreased levels of Cys-LT, LTB4, peribronchial and perivascular inflammation, but no significant changes were observed in AHR, hydroxyproline level, goblet cell hyperplasia, and mucus hyper-secretion. Ganoderma can be applied as an immunomodulatory and anti-inflammatory agent for managing asthma.

• Authors: Yanfeng Li, Miaomiao Li, Rui Wang, Biyu Wang, Seyyed Shamsadin Athari, Jinli Wang
• Journal: Respiratory physiology & neurobiology (Respir Physiol Neurobiol) Vol. 299 Pg. 103843 (05 2022) ISSN: 1878-1519 [Electronic] Netherlands
• PMID: 35026480 (Publication Type: Journal Article)
• Copyright: Copyright © 2022. Published by Elsevier B.V.

Chemical References

• Anti-Inflammatory Agents
• Cytokines
• Leukotriene B4
• Ovalbumin
• Hydroxyproline

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Asthma (drug therapy, pathology)
• Bronchoalveolar Lavage Fluid
• Cytokines
• Disease Models, Animal
• Ganoderma
• Hydroxyproline (therapeutic use)
• Hyperplasia (pathology)
• Inflammation (drug therapy, pathology)
• Leukotriene B4 (therapeutic use)
• Lung (pathology)
• Mice
• Mice, Inbred BALB C
• Ovalbumin