Extracellular vesicles in vascular remodeling.

Abstract

Vascular remodeling contributes to the development of a variety of vascular diseases including hypertension and atherosclerosis. Phenotypic transformation of vascular cells, oxidative stress, inflammation and vascular calcification are closely associated with vascular remodeling. Extracellular vesicles (EVs) are naturally released from almost all types of cells and can be detected in nearly all body fluids including blood and urine. EVs affect vascular oxidative stress, inflammation, calcification, and lipid plaque formation; and thereby impact vascular remodeling in a variety of cardiovascular diseases. EVs may be used as biomarkers for diagnosis and prognosis, and therapeutic strategies for vascular remodeling and cardiovascular diseases. This review includes a comprehensive analysis of the roles of EVs in the vascular remodeling in vascular diseases, and the prospects of EVs in the diagnosis and treatment of vascular diseases.

• Authors: Chao Ye, Fen Zheng, Nan Wu, Guo-Qing Zhu, Xiu-Zhen Li
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 43 Issue 9 Pg. 2191-2201 (Sep 2022) ISSN: 1745-7254 [Electronic] United States
• PMID: 35022541 (Publication Type: Journal Article, Review)
• Copyright: © 2022. The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society.

Topics

• Atherosclerosis
• Cardiovascular Diseases
• Extracellular Vesicles
• Humans
• Inflammation
• Vascular Remodeling