Does CCL19 act as a double-edged sword in cancer development?

Abstract

Cancer is considered a life-threatening disease, and several factors are involved in its development. Chemokines are small proteins that physiologically exert pivotal roles in lymphoid and non-lymphoid tissues. The imbalance or dysregulation of chemokines has contributed to the development of several diseases, especially cancer. CCL19 is one of the homeostatic chemokines that is abundantly expressed in the thymus and lymph nodes. This chemokine, which primarily regulates immune cell trafficking, is involved in cancer development. Through the induction of anti-tumor immune responses and inhibition of angiogenesis, CCL19 exerts tumor-suppressive functions. In contrast, CCL19 also acts as a tumor-supportive factor by inducing inflammation, cell growth, and metastasis. Moreover, CCL19 dysregulation in several cancers, including colorectal, breast, pancreatic, and lung cancers, has been considered a tumor biomarker for diagnosis and prognosis. Using CCL19-based therapeutic approaches has also been proposed to overcome cancer development. This review will shed more light on the multifarious function of CCL19 in cancer and elucidate its application in diagnosis, prognosis, and even therapy. It is expected that the study of CCL19 in cancer might be promising to broaden our knowledge of cancer development and might introduce novel approaches in cancer management.

• Authors: Arezoo Gowhari Shabgah, Zaid Mahdi Jaber Al-Obaidi, Heshu Sulaiman Rahman, Walid Kamal Abdelbasset, Wanich Suksatan, Dmitry O Bokov, Lakshmi Thangavelu, Abduladheem Turki Jalil, Farhad Jadidi-Niaragh, Hamed Mohammadi, Kazem Mashayekhi, Jamshid Gholizadeh Navashenaq
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 207 Issue 2 Pg. 164-175 (04 04 2022) ISSN: 1365-2249 [Electronic] England
• PMID: 35020885 (Publication Type: Journal Article, Review)
• Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• CCL19 protein, human
• Chemokine CCL19
• Chemokines
• Receptors, CCR7

Topics

• Chemokine CCL19 (metabolism)
• Chemokines (metabolism)
• Humans
• Lung Neoplasms (metabolism)
• Lymph Nodes
• Neovascularization, Pathologic
• Prognosis
• Receptors, CCR7 (metabolism)