Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing Protein.

Abstract

Melanoma differentiation associated gene-7/interleukin-24 (MDA-7/IL-24), a secreted protein of the IL-10 family, was first identified more than two decades ago as a novel gene differentially expressed in terminally differentiating human metastatic melanoma cells. MDA-7/IL-24 functions as a potent tumor suppressor exerting a diverse array of functions including the inhibition of tumor growth, invasion, angiogenesis, and metastasis, and induction of potent "bystander" antitumor activity and synergy with conventional cancer therapeutics. MDA-7/IL-24 induces cancer-specific cell death through apoptosis or toxic autophagy, which was initially established in vitro and in preclinical animal models in vivo and later in a Phase I clinical trial in patients with advanced cancers. This review summarizes the history and our current understanding of the molecular/biological mechanisms of MDA-7/IL-24 action rendering it a potent cancer suppressor.

• Authors: Jinkal Modi, Abhishek Roy, Anjan K Pradhan, Amit Kumar, Sarmistha Talukdar, Praveen Bhoopathi, Santanu Maji, Padmanabhan Mannangatti, Daniel Sanchez De La Rosa, Jiong Li, Chunqing Guo, Mark A Subler, Jolene J Windle, Webster K Cavenee, Devanand Sarkar, Xiang-Yang Wang, Swadesh K Das, Luni Emdad, Paul B Fisher
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 23 Issue 1 (Dec 22 2021) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 35008495 (Publication Type: Journal Article, Review)

Chemical References

• Interleukins
• Tumor Suppressor Proteins
• interleukin-24

Topics

• Animals
• Apoptosis (physiology)
• Autophagy (physiology)
• Cell Death (physiology)
• Humans
• Interleukins (metabolism)
• Melanoma (metabolism)
• Tumor Suppressor Proteins (metabolism)