β-Cyclodextrin-Derivative-Functionalized Graphene Oxide/Graphitic Carbon Nitride Composites with a Synergistic Effect for Rapid and Efficient Sterilization.

Abstract

The nonselectivity of phototherapy and the hydrophobicity of phototherapy agents limit their application in the treatment of antibiotic-resistant bacteria. In this work, β-cyclodextrin-derivative-functionalized graphene oxide (GO)/graphitic carbon nitride (g-C3N4) antibacterial materials (CDM/GO/CN) were designed and synthesized. CN is used as a photosensitizer for photodynamic therapy (PDT) and GO as a photothermal agent for photothermal therapy (PTT). In addition, the supramolecular host-guest complex on the substrate can not only increase the inherent water solubility of the substrate and reduce the aggregation of the photosensitizer/photothermal agent but also manipulate the interaction between the photosensitizer/photothermal agent and bacteria to capture specific bacteria. The hyperthermia caused by PTT denatures proteins on the cell membrane, allowing reactive oxygen species (ROS) to enter the cell better and kill bacteria. The specific capture of Escherichia coli CICC 20091 by mannose significantly improves the sterilization efficiency and reduces side effects. The synergistic antibacterial agent shows excellent antibacterial efficacy of over 99.25% against E. coli CICC 20091 after 10 min of 635 + 808 nm dual-light irradiation. Moreover, cell proliferation experiments show that the composite material has good biocompatibility, expected to have applications in bacterial infections.

• Authors: Ting Wang, Zhenlong Bai, Wei Wei, Fengming Hou, Wei Guo, Ang Wei
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 14 Issue 1 Pg. 474-483 (Jan 12 2022) ISSN: 1944-8252 [Electronic] United States
• PMID: 34978185 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Biocompatible Materials
• Nitrogen Compounds
• Photosensitizing Agents
• Reactive Oxygen Species
• beta-Cyclodextrins
• graphene oxide
• graphitic carbon nitride
• Graphite
• betadex

Topics

• Anti-Bacterial Agents (chemical synthesis, chemistry, pharmacology)
• Biocompatible Materials (chemical synthesis, chemistry, pharmacology)
• Cell Line
• Escherichia coli (drug effects)
• Graphite (chemistry, pharmacology)
• Humans
• Materials Testing
• Microbial Sensitivity Tests
• Nitrogen Compounds (chemistry, pharmacology)
• Photochemotherapy
• Photosensitizing Agents (chemical synthesis, chemistry, pharmacology)
• Reactive Oxygen Species (metabolism)
• beta-Cyclodextrins (chemistry, pharmacology)