Myocarditis is an inflammatory disease of the myocardium that mostly affects young adults. The disease is commonly caused by
viral infection, medications, autoimmune disorders, and inflammatory conditions. Nearly 50% of the cases of
myocarditis are due to post-viral immune response in a setting of an identifiable or non-identifiable
infection. The clinical manifestation is nonspecific ranging from asymptomatic courses to
sudden death in infants and young patients. This review describes the properties of
phytochemicals as plant-derived active ingredients which can be used in the prevention and treatment of
myocarditis and its associated risk factors. Meanwhile, it has illustrated epidemiological analyses, mechanism of action, and the metabolism of
phytochemicals in animal and human clinical trials. We also mentioned the precise mechanism of action by which
phytochemicals elicit their anti-viral, anti-inflammatory,
antioxidant, and immunomodulatory effects and how they regulate signal transduction pathways. Nevertheless, comprehensive clinical trials are required to study the properties of
phytochemicals in vivo, in vitro, and in silico for a proper management of
myocarditis. Our findings indicate that
phytochemicals function as potent adjunctive therapeutic drugs in
myocarditis and its related complications.