COVID 19 pandemic and mass vaccination campaigns have revealed the situation of the most vulnerable patients. In this work, we focused our attention to patients who have
Multiple Sclerosis (MS), particularly in treatment with
cladribine tablets, trying to understand if and when it is possible to administer the
vaccine successfully. In light of the novel topic, we studied the existing literature and analysed experiences with previous vaccinations, such as
influenza and VZV, as well as data from countries where vaccination campaigns had already begun. Overall, we have taken into account the mechanism of action, the pharmacokinetic/pharmacodynamic of
cladribine, and the changes in the immune system after its administration, together with the preliminary data about the humoral response to
influenza, VZV, and SARS-CoV-2 vaccinations in
cladribine treated patients. In conclusion, data showed that the use of
cladribine tablets seems to permit flexibility regarding vaccination timing and we suggest that vaccination in those patients should be safe and effective. The current
COVID 19 pandemic has re-ignited the interest in
vaccines and vaccination procedures. The importance of including fragile individuals has increased as a result of mass vaccination. Millions of patients with
multiple sclerosis (MS) around the world are debating whether they can safely receive their
vaccine shot with the same efficacy despite receiving immune-modulating or immune-suppressive treatments. In the absence of conclusive empirical data, we will review and discuss the available evidence and the reasonable conclusions for one specific treatment, namely
cladribine tablets (Mavenclad).