Abstract | AIMS: MAIN METHODS: KEY FINDINGS: SIGNIFICANCE: These findings suggest that hepatocellular carcinoma induces body mass loss in parallel with activation of the water conservation system including aldosterone secretion and urea accumulation to retain osmolyte and water. The osmolyte and water retention at the tissue level may be a causative factor for ascites and edema formation in liver failure rats.
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Authors | Satoshi Kidoguchi, Kento Kitada, Kazuki Nakajima, Daisuke Nakano, Hiroyuki Ohsaki, Wararat Kittikulsuth, Hideki Kobara, Tsutomu Masaki, Takashi Yokoo, Kazuo Takahashi, Jens Titze, Akira Nishiyama |
Journal | Life sciences
(Life Sci)
Vol. 289
Pg. 120192
(Jan 15 2022)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 34871664
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Chemical References |
- Mineralocorticoid Receptor Antagonists
- Neoplasm Proteins
- Receptors, Mineralocorticoid
- Spironolactone
- Diethylnitrosamine
- Aldosterone
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Topics |
- Aldosterone
(urine)
- Animals
- Carcinoma, Hepatocellular
(chemically induced, drug therapy, urine)
- Diethylnitrosamine
(toxicity)
- Liver Neoplasms, Experimental
(chemically induced, drug therapy, urine)
- Male
- Mineralocorticoid Receptor Antagonists
(pharmacology)
- Neoplasm Proteins
(antagonists & inhibitors, metabolism)
- Rats
- Rats, Inbred WKY
- Receptors, Mineralocorticoid
(metabolism)
- Spironolactone
(pharmacology)
- Water-Electrolyte Balance
- Weight Loss
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