Abstract | INTRODUCTION: Hepatobiliary abnormalities occur commonly in sickle cell anaemia and these have been extensively reported in the adult patients. However, complications have been sparsely reported in children especially in the sub-Saharan African continent. This study aimed to highlight the hepatobiliary complications in this group of children using clinical examination, laboratory testing and abdominal ultrasonography. The challenges in a resource limited country are also highlighted. SUBJECTS, MATERIALS AND METHODS: One hundred and thirty- four (134) children aged 1-18years with sickle cell anaemia in steady state were recruited into this crossectional study. Clinical history and physical examination obtained were documented. Relevant basic haematologic and biochemical indices (Full blood count, liver enzymes and viral markers for hepatitis B and C) and abdominal ultrasonographic parameters were documented for all the children. The relationship between the complications and possible risk factors (age, frequency of crisis and blood transfusions) were also documented. RESULT: CONCLUSION: Hepatobiliary abnormalities are prevalent in children with sickle cell anaemia. Clinical screening and the use of ultrasonography would aid early diagnosis and appropriate therapeutic intervention in this group of children.
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Authors | O F Adeniyi, A M Akinsete, E A Odeghe, O F Okeke, O Mokwenyei, B Kene-Udemezue, J O Seyi-Olajide, A Akinsulie, O Adeniran, O Adeniran, G Oyeleke |
Journal | West African journal of medicine
(West Afr J Med)
Vol. Vol. 38
Issue 10
Pg. 917-923
(Oct 29 2021)
ISSN: 0189-160X [Print] Nigeria |
PMID | 34855316
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 by West African Journal of Medicine. |
Chemical References |
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Topics |
- Aged
- Anemia, Sickle Cell
(complications, epidemiology)
- Blood Transfusion
- Humans
- Hydroxyurea
- Male
- Nigeria
- Ultrasonography
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