Design and construction of IR780- and EGCG-based and mitochondrial targeting nanoparticles and their application in tumor chemo-phototherapy.

Abstract

An integration combination of phototherapy and chemotherapy to treat carcinoma, solving the inner limitation of individual-modal chemical agent-based therapy or phototherapy, emerges to be a strategy with high prospects for achieving synergistic curative effects. The dye IR780-iodide (IR780) close to infrared radiation is a phototherapy agent with high prospects. However, it is limited in its clinical applications due to poor solubility in water. While epigallocatechin-3-gallate (EGCG), naturally resourced green tea polyphenol, has been extensively proven with intrinsic antitumor activity, but it is largely restricted by its low bioavailability in vivo. Hence, novel multiple-function nanoparticles comprising hyaluronic acid (HA) and IR780 were proposed to deliver EGCG, defined as EGCG@THSI nano-scale particles (EGCG@THSI NPs), thereby rapidly solving limitations of EGCG and IR780. Amphiphilic nano-scale carrier was prepared by triphenylphosphine (TPP), hyaluronic acid (HA), cystamine, and IR780, termed as TPP-HA-SS-IR780, and EGCG was loaded into the amphiphilic copolymer by self-assembly. TPP-HA-SS-IR780 endowed the as-synthesized EGCG@THSI NPs with excellent TPP-mediated mitochondrial-targeted and glutathione-triggered rapid drug release properties. As impacted by the integration of phototherapy and chemotherapy, the EGCG@THSI NPs under NIR laser irradiation showed a prominent anti-tumor effect. Taken together, this study presented a multiple-function nano-scale carrier platform with high prospects in improving the therapeutic efficacy of anti-carcinoma drugs.

• Authors: Jiahe Bao, Yinan Zhao, Jing Xu, Yuanqiang Guo
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 9 Issue 48 Pg. 9932-9945 (12 15 2021) ISSN: 2050-7518 [Electronic] England
• PMID: 34842269 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium
• Antineoplastic Agents
• Fluorescent Dyes
• Indoles
• Iodides
• Photosensitizing Agents
• Catechin
• epigallocatechin gallate

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Catechin (analogs & derivatives, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Drug Design
• Drug Screening Assays, Antitumor
• Fluorescent Dyes (chemical synthesis, chemistry, pharmacology)
• Humans
• Indoles (chemistry, pharmacology)
• Iodides (chemistry, pharmacology)
• Materials Testing
• Mitochondria (drug effects, metabolism)
• Molecular Structure
• Nanoparticles (chemistry)
• Neoplasms, Experimental (drug therapy, metabolism, pathology)
• Photosensitizing Agents (chemical synthesis, chemistry, pharmacology)
• Photothermal Therapy
• Zebrafish