Dietary intake of
B vitamins and
methionine might associate with
carcinogenesis due to their role in
DNA synthesis and methylation. Owing to the previous inconsistent findings on
gastric cancer risk, we aimed to examine the associations between dietary intakes of
B vitamins and
methionine and the risk of
gastric cancer, according to
sodium intake.We included 86,820 Japanese individuals who completed a validated food frequency questionnaire with 138 food items in the Japan Public Health Center-based Prospective Study. Cox proportional hazards regression was used to obtain HRs and 95% confidence intervals (CI) of
gastric cancer according to separate intakes of
folate,
vitamin B6,
vitamin B12, and
methionine after adjusting for confounding factors, including Helicobacter pylori and
atrophic gastritis in the subgroup analysis.We identified 2,269
gastric cancer cases within a median of 15.4 years of follow-up. We found no association between any of the dietary intakes of
folate,
vitamin B6,
vitamin B12, or
methionine with the risk of
gastric cancer. In the stratified analysis by
sodium intake, we observed a positive association between
folate intake and risk of
gastric cancer among participants with a high
sodium intake (≥4.5 g/day) [HR = 1.28 (95% CI, 1.06-1.56), P trend = 0.001; P interaction = 0.02]. Meanwhile, there was no association between
folate intake and risk of
gastric cancer among participants with low
sodium intake (<4.5 g/day) [HR = 0.94 (95% CI, 0.73-1.21), P trend = 0.49].In conclusion, we found no association between any dietary intakes of
folate,
vitamin B6,
vitamin B12, and
methionine with the risk of
gastric cancer. PREVENTION RELEVANCE: The increased intake of
B vitamins and
methionine in populations with adequate dietary intake of these nutrients showed no association with the risk of
gastric cancer.