Background: In addition to the cardiovascular and renal systems, the gastrointestinal tract also contains
angiotensin ATR1a, ATR1b, and ATR2. We previously observed that the 2Kidney-1Clip
hypertension model elicits physical exercise and gastrointestinal dysmotility, which is prevented by renin-angiotensin system blockers. Here, we investigate the effect of physical exercise on
inflammation, stress
biomarkers, and
angiotensin II receptors in the duodenum of 2K1C rats. Methods: Arterial
hypertension was induced by the 2K1C surgical model. The rats were allocated in
Sham, 2K1C, or 2K1C+Exercise groups. One week after surgery, they were submitted to a physical exercise protocol (running 5x/week, 60min/day). Next, we assessed their intestinal contractility,
cytokine levels (TNF-α, IL-1β, and IL-6), oxidative stress levels (MPO, GSH, MDA, and SOD), and the gene expression of
angiotensin receptors (ATR1A, ATR1B, and ATR2). Results: In comparison with the
Sham group, the 2K1C arterial
hypertension decreased (p<0.05) the intestinal contractility. In comparison with 2K1C, the 2K1C+Exercise group exhibited lower (p<0.05) MPO activity (22.04±5.90 vs. 78.95±18.09 UMPO/mg tissue) and higher (p<0.05) GSH concentrations in intestinal tissues (67.63±7.85 vs. 31.85±5.90mg NPSH/mg tissue). The 2K1C+Exercise group showed lower (p<0.05)
cytokine levels in the intestine than 2K1C rats. In comparison with the
Sham group, the 2K1C+Exercise rats showed higher (p<0.05) gene expression of ATR2 in the duodenum. Conclusion: 2K-1C
hypertension elicits an oxidative stress and
inflammation process in the duodenum. Physical exercise modulates the expression twice as much of ATR2 receptors, suggesting possible anti-inflammatory and
antioxidant effects induced by exercise.