RANTES is implicated in allergic
asthma and in T cell-dependent clearance of
infection.
RANTES receptor family comprises CCR1, CCR3, and CCR5, which are
G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of
RANTES production by epithelial cells. Here, we studied the role of
RANTES in the peripheral blood mononuclear cells in cohorts of children with and without
asthma and validated and extended this study to the airways of adults with and without
asthma. We further translated these studies to a murine model of
asthma induced by house dust mite
allergen in wild-type
RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of
RANTES in the resolution of
allergen-induced
asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased
IL-10 production in the lung.