Abstract | BACKGROUND & AIMS: METHODS: We investigated the associations between MetS and gastrointestinal cancer risk (overall, colorectal, pancreatic, esophageal adenocarcinoma, esophageal squamous cell carcinoma, stomach cardia, stomach non-cardia, hepatocellular carcinoma, and intrahepatic bile duct cancer) in 366,016 United Kingdom Biobank participants with comprehensive serum biomarker and genotype data. MetS status was determined by 3 different definitions at baseline, and, in 15,152 participants, at a repeat assessment after a median of 4.3 years of follow-up. Multivariable hazard ratios and 95% confidence intervals for cancer outcomes were estimated using Cox proportional hazards models. Analyses stratified by polygenic risk score were conducted for colorectal and pancreatic cancers. RESULTS: During a median follow-up of 7.1 years, 4238 incident cases of a gastrointestinal cancer occurred. MetS at baseline was associated with higher risk of overall gastrointestinal cancer by any definition (hazard ratio, 1.21; 95% confidence interval, 1.13-1.29, harmonized definition). MetS was associated with increased risks of colorectal cancer, colon cancer, rectal cancer, hepatocellular carcinoma, pancreatic cancer in women, and esophageal adenocarcinoma in men. Associations for colorectal cancer and pancreatic cancer did not differ by polygenic risk score strata (P-heterogeneity 0.70 and 0.69, respectively), and 80% of participants with MetS at baseline retained this status at the repeat assessment. CONCLUSIONS:
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Authors | Joseph A Rothwell, Mazda Jenab, Mojgan Karimi, Thérèse Truong, Yahya Mahamat-Saleh, Pietro Ferrari, S Ghazaleh Dashti, Tilman Kühn, Amanda J Cross, Gianluca Severi, Marc J Gunter, Neil Murphy |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 20
Issue 6
Pg. e1338-e1352
(06 2022)
ISSN: 1542-7714 [Electronic] United States |
PMID | 34687971
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022. Published by Elsevier Inc. |
Topics |
- Adenocarcinoma
(complications)
- Carcinoma, Hepatocellular
(complications)
- Esophageal Neoplasms
(complications)
- Esophageal Squamous Cell Carcinoma
(epidemiology)
- Female
- Humans
- Liver Neoplasms
(complications)
- Male
- Metabolic Syndrome
(complications, epidemiology)
- Pancreatic Neoplasms
(complications)
- Prospective Studies
- Rectal Neoplasms
- Risk Factors
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