[Role of exosomal miRNA in tumor progression and its possible mechanism].

Abstract

Exosome is a kind of biological nano-vesicle with a diameter of about 30-100 nm and is synthesized, secreted, and released in almost all types of body cells. Recent studies have found that exosomes contain a variety of functional proteins, including mRNA and microRNAs (miRNAs) and so on, which play an important role in the process of material transfer and information exchange in cells. In addition, the related-exosomal microRNAs secreted by tumor cells play an important role in regulating theoccurrence, development, invasion and metastasis of tumors and other biological processes.. Therefore, the study of tumor-related exosomal microRNAs will help us to explore the mechanism of tumor progression from the perspective of tumor gene regulation and new tumor markers, which will contribute to the early diagnosis, treatment, disease monitoring and prognosis evaluation.

• Authors: L Wu, Z G Tang, S W Li, W Wang, L Ye, L C Yao
• Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi) Vol. 29 Issue 9 Pg. 908-912 (Sep 20 2021) ISSN: 1007-3418 [Print] China
• PMID: 34638218 (Publication Type: Journal Article)

Chemical References

• MicroRNAs
• RNA, Messenger

Topics

• Exosomes (genetics)
• Humans
• MicroRNAs (genetics)
• Neoplasms (genetics)
• Prognosis
• RNA, Messenger