Real-world outcomes of second novel hormonal therapy or radium-223 following first novel hormonal therapy for mCRPC.
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| Abstract |
Aim: To evaluate real-world clinical outcomes of radium-223 or alternative novel hormonal therapy (NHT) following first-line NHT for metastatic castration-resistant prostate cancer (mCRPC). Patients & methods: Retrospective analysis of the US Flatiron database (ClinicalTrials.gov identifier: NCT03896984). Results: In the radium-223 cohort (n = 120) versus the alternative NHT cohort (n = 226), proportionally more patients had prior symptomatic skeletal events and bone-only metastases, and first-line NHT duration was shorter. Following second-line therapy, 49 versus 39% of patients received subsequent life-prolonging therapy; of these, 47 versus 76% received taxane. Median overall survival was 10.8 versus 11.2 months. Conclusion: Real-world patients with mCRPC had similar median overall survival following second-line radium-223 or alternative NHT after first-line NHT. Many patients received subsequent therapy, with less taxane use after radium-223.
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| Authors | Oliver Sartor, Daniel George, Bertrand Tombal, Neeraj Agarwal, Celestia S Higano, Cora N Sternberg, Kurt Miller, XiaoLong Jiao, Helen Guo, Per Sandström, Amanda Bruno, Frank Verholen, Fred Saad, Neal Shore |
| Journal | Future oncology (London, England) (Future Oncol) Vol. 18 Issue 1 Pg. 35-45 (Jan 2022) ISSN: 1744-8301 [Electronic] England |
| PMID | 34636627 (Publication Type: Journal Article) |
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