Peritoneal
metastasis is an advanced
cancer type which can be treated with pressurized intraperitoneal
aerosol chemotherapy (PIPAC). Here, chemotherapeutics are nebulized under high pressure in the intraperitoneal (IP) cavity to obtain a better biodistribution and
tumor penetration. To prevent the fast leakage of chemotherapeutics from the IP cavity, however, nebulization of
controlled release formulations is of interest. In this study, the potential of the thermosensitive
hydrogel Pluronic F127 to be applied by high pressure nebulization is evaluated. Therefore,
aerosol formation is experimentally examined by
laser diffraction and theoretically simulated by computational fluid dynamics (CFD) modelling. Furthermore,
Pluronic F127 hydrogels are subjected to rheological characterization after which the release of fluorescent model nanoparticles from the
hydrogels is determined. A delicate equilibrium is observed between controlled release properties and suitability for aerosolization, where denser
hydrogels (20% and 25% w/v
Pluronic F127) are able to sustain nanoparticle release up to 30 h, but cannot effectively be nebulized and vice versa. This is demonstrated by a growing
aerosol droplet size and exponentially decreasing
aerosol cone angle when
Pluronic F127 concentration and viscosity increase. Novel nozzle designs or alternative
controlled release formulations could move intraperitoneal drug delivery by high pressure nebulization forward.