Abstract | BACKGROUND: METHODS: CSF NLK levels were quantified by ELISA in CAA patients (n = 25) and controls (n = 27) and in two independent samples of aMCI patients, AD patients, and controls: (1) From the Radboud University Medical Center (Nijmegen), we included n = 19 aMCI patients, n = 40 AD patients, and n = 32 controls. (2) From the Hospital of Sant Pau (Barcelona), we included n = 33 aMCI patients, n = 17 AD patients, and n = 50 controls. RESULTS: CSF NLK levels were similar in CAA patients and controls (p = 0.95). However, we found an elevated CSF concentration of NLK in aMCI (p < 0.0001) and AD patients (p < 0.0001) compared to controls in both samples sets. In addition, we found a correlation of CSF NLK with CSF YKL-40 (age-adjusted-spearman-rank-coefficient = 0.82, p < 0.0001) in aMCI/AD patients, a well-known glial marker of neuro- inflammation. CONCLUSIONS: We found that CSF NLK levels are elevated in aMCI and AD patients compared to controls, but are not increased in CAA patients. CSF NLK levels may be related to an increased neuroinflammatory state in early stages of AD, given its association with YKL-40.
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Authors | Anna M De Kort, H Bea Kuiperij, Daniel Alcolea, Iris Kersten, Alexandra A M Versleijen, Steven M Greenberg, Erik Stoops, Floris H B M Schreuder, Catharina J M Klijn, Alberto Lleó, Jurgen A H R Claassen, Marcel M Verbeek |
Journal | Alzheimer's research & therapy
(Alzheimers Res Ther)
Vol. 13
Issue 1
Pg. 160
(09 24 2021)
ISSN: 1758-9193 [Electronic] England |
PMID | 34560885
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Amyloid beta-Peptides
- Biomarkers
- Nerve Growth Factors
- NLK protein, human
- Protein Serine-Threonine Kinases
- Glucose-6-Phosphate Isomerase
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Topics |
- Alzheimer Disease
(complications)
- Amyloid beta-Peptides
- Biomarkers
- Cerebral Amyloid Angiopathy
(complications)
- Glucose-6-Phosphate Isomerase
- Humans
- Nerve Growth Factors
- Protein Serine-Threonine Kinases
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